search

HKU-BAL / Clair3

Clair3 - Symphonizing pileup and full-alignment for high-performance long-read variant calling
246 stars 27 forks source link

Clair3 with polyploids #331

Closed ewoutcrombez closed 2 months ago

ewoutcrombez commented 3 months ago

Hello,

Thank you very much for the development of this tool! I saw in the README that it is possible to call variants in non-diploid organisms. Is this meant for polyploid genomes? And in what way does it differ with the diploid variant calling? I do not seem to find anything about it in the publication and I would like to use Clair3 for tetraploid data. Many thanks in advance.

zhengzhenxian commented 3 months ago

Basically no. Clair3 applies a strong diploid assumption to its output.