MiraldiLab / maxATAC

Transcription Factor Binding Prediction from ATAC-seq and scATAC-seq with Deep Neural Networks
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Update predict.md #124

Closed ANRudrapatna closed 7 months ago

ANRudrapatna commented 10 months ago

Removed "peaks" as an option for maxATAC, given potential issues with the peak-centric mode in maxATAC.

emiraldi commented 7 months ago

I agree with Xiaoting -- provided peak centric is working as expected (predictions limited to a set of .bed intervals), let's keep it. As I recall, there might have been some issue that peak centric sometimes outputted predictions outside of the .bed intervals, due to overhang -- but this should be easy to fix with a bedtools intersection clean-up step at the end.

ANRudrapatna commented 7 months ago

Hello everybody:

This is likely an edit I proposed for v1.0.5, where prediction restricted to an input set of intervals did not work (see some of my previous emails comparing whole-genome vs. "peak-centric" mode for maxATAC predict). It looks like this now works in v1.0.6, so we can ignore these edits!

Please let me know if you have any questions!

Akshata Rudrapatna


From: Emily Miraldi @.> Sent: Tuesday, January 23, 2024 2:03:08 PM To: MiraldiLab/maxATAC @.> Cc: Rudrapatna, Akshata (rudrapan) @.>; Author @.> Subject: Re: [MiraldiLab/maxATAC] Update predict.md (PR #124)

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I agree with Xiaoting -- provided peak centric is working as expected (predictions limited to a set of .bed intervals), let's keep it. As I recall, there might have been some issue that peak centric sometimes outputted predictions outside of the .bed intervals, due to overhang -- but this should be easy to fix with a bedtools intersection clean-up step at the end.

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