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Nanostring-Biostats / SpatialDecon

The SpatialDecon library implements the SpatialDecon algorithm for mixed cell deconvolution in spatial gene expression datasets. (This algorithm also works in bulk expression profiling data.)
MIT License
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Error: NaNs produced, Unsuccessful Convergence #42

Open Goralsth opened 2 years ago

Goralsth commented 2 years ago

Hello, while running the spatialdecon function I have been receiving error messages Warning NaNs produced, Warning Unsuccessful Convergence. What leads to the production of NaNs. I understand that unsuccessful convergence can occur in regression models of particularly high complexity and mixed effects (this problem does persist even out to hundreds of thousands of iterations), but this hasn't been a problem for previous analysis of GeoMx data.

are the NaNs are result of unsuccessful convergence, or the cause? Is there a known way to fix this issue?

maddygriz commented 2 years ago

Hi @Goralsth,

Sorry for the late response, I have been out of the office for the past couple days. Our customer support team will be able to help you with this. Please email geomxsupport@nanostring.com with your issue.

Thanks, Maddy