Open-Systems-Pharmacology / Carbamazepine-Model

PBPK model of carbamazepine as CYP3A4 and CYP2B6 substrate and inducer
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Lipophilicity value for CBZE differs from publication #2

Closed AndreDlm closed 1 year ago

AndreDlm commented 2 years ago

In the carbamazepine model v1.0, the lipophilicity of carbamazepine-10,11-epoxide (CBZE) is 1.16, whereas in the publication a value of 1.00 is reported (Table 1).

@LMFuhr could you advise which of the two values is the correct one? Thanks!

Note: This issue applies only to the carbamazepine model v1.0; carbamazepine model v1.1 does not include CBZE