Hello!
I am referring to the reply to a discussion on the difference between the fraction unbound plasma vs experiment:
The Fraction unbound (experiment) is used for calculation of the specific renal clearance rate constant from renal clearance input value. So to correctly apply the measured or predicted renal clearance value to the model, the two Fraction unbound parameters should be equal. You should also consider this during parameter identification, if you are optimizing the fraction unbound.
Originally posted by @PavelBal in https://github.com/Open-Systems-Pharmacology/Forum/discussions/1452#discussioncomment-4956564
My question is: if the two fraction unbound values must be equal and I want to do parameter identification, I must select both of them as Identification Parameters. However, the optimized values may not be identical. Is there a way to force the two values to be identical?
Looking forward to your reply.
Thanks
Hello! I am referring to the reply to a discussion on the difference between the fraction unbound plasma vs experiment: The
Fraction unbound (experiment)is used for calculation of the specific renal clearance rate constant from renal clearance input value. So to correctly apply the measured or predicted renal clearance value to the model, the twoFraction unboundparameters should be equal. You should also consider this during parameter identification, if you are optimizing the fraction unbound. Originally posted by @PavelBal in https://github.com/Open-Systems-Pharmacology/Forum/discussions/1452#discussioncomment-4956564My question is: if the two fraction unbound values must be equal and I want to do parameter identification, I must select both of them as Identification Parameters. However, the optimized values may not be identical. Is there a way to force the two values to be identical?
Looking forward to your reply. Thanks