search

Open-Systems-Pharmacology / Forum

Discussion forum for the Open Systems Pharmacology Project
65 stars 19 forks source link

How to calculate the GMFE? #612

Closed andanteyang closed 3 years ago

andanteyang commented 4 years ago

Hi everyone,

Is there a function for calculating the GMFE and/or plotting the GOFMergedPlots embedded in PKsim/Mobi? If there is any other parameters to evaluate/compare the fitness between different models?

Many thanks!

prvmalik commented 4 years ago

At present, there is no automated way to do this. I use 2 manual methods, depending on the amount of data that I am working with.

A. Export the simulation results to .csv and manually calculate predicted/observed.

B. Run a parameter identification with all the desired simulations for evaluation. Set 0 identification runs, linear scaling on the datasets and linear scaling on the parameters (very important!). Then you can export the time profile analysis and the residual analysis to get the data that you need for GMFE on a larger scale.

When doing this, you must be extremely careful that the units of the concentration are all the same for the observed datasets and the simulations.