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Peptide in PK-SIM #622

Closed Boulenc closed 3 years ago

Boulenc commented 4 years ago

Dear community, I am looking for examples of PBPK modelling in PK-SIM with peptide. With ‘’peptide’’, I mean compound of around 1-2 kDa as MW, without Fc part. I am interested in tissue distribution of such modality. Any literature available? Thank you for your help. Xavier

StephanSchaller commented 4 years ago

Dear Xavier,

the publication on the protein (2-pore) model from PK-Sim also covers a peptide (inulin, no Fc binding) with around 5.5 kDa (Tissue distribution in Figure 12). From the top of my head, I don't know of any publications on a 1-2 kDa compound where tissue data are available.

Best, Stephan

Boulenc commented 4 years ago

Thank you Stephan, Indeed, Inulin (polysacharide) with small MW, without Fc part, and thereby rapid elimination and diffusion, can be considered to have a behaviour close to a peptide I guess. Best Regards. Xavier.