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implementation of peripheral venous blood in Mobi for PD modeling #715

Closed CK-CHO closed 3 years ago

CK-CHO commented 3 years ago

Hello, i have a questions about implementation of peripheral venous plasma concentration.

I didn't find the peripheral venous plasma concentration in possible referenced objects in new parameters of spatial structures. Provided peripheral venous blood compartment were not clicked in the software.

PD 질문 1

How can i incorporating the plasma concentration-time profiles in the PD model?

When i used the table (multiple time discrete and piecewise constant numeric values) in specific time point nor the formula (an explicit formula) values, i confirmed that PD model is plausible. So, i want to incorporate the simulated profiles in the PD model, not the specific table for improvement of our model.

PD 질문 3

Please give me the opinion and help.

Thank you.

PavelBal commented 3 years ago

Hi,

the "PeripheralVenousBlood" is an observer. It is mixture of the concentrations in Muscle and Fat plasma. Observers cannot be used in equations. Instead, you can use the "VenousBlood|Plasma" concentrations, which should be very close to the PeripheralVenousBlood unless your compound is extensively metabolized in muscle and/or fat.