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Physiological fluid volume in the gut #728

Closed Boulenc closed 3 years ago

Boulenc commented 3 years ago

I am struggling with bioparmaceutical aspects after oral route. Do you know if the the fluid volume in the gut can be changed?; what is the default value? I can change easily the volume of administration (3.5 mL/kg) in the ''Administration'' building block but not this physiological volume for human. This value should impact the solubilized dose fraction in the gut. Thank you for your help. Xavier

StephanSchaller commented 3 years ago

Hi Xavier,

you can change this once you have set up the simulation in the administration protocol (oral administration): image

Boulenc commented 3 years ago

Hi Stephan, OK for the administration volume, but I am talking about physiological fluid volume in the gut. is it 0 by default?

StephanSchaller commented 3 years ago

Sorry, my misunderstanding...

You can change this via the fraction of stomach volume filled with liquid ... the parameter is called "Fractional steady state fill level": It can be found here: image

The liquid volume is the product of "Fractional steady state fill level" and "Volume"

Boulenc commented 3 years ago

I Stephan,

Thank you. Is 1.57 L the fluid volume ? of the total volume (empty and full) ?; it is high, BCS/DCS classification assume 250 mL and now 500 mL in total, with about 250 mL as water administration volume. Can grey area be changed?

Regards

Xavier.

De : esqlabs GmbH @.> Envoyé : mercredi 5 mai 2021 16:10 À : Open-Systems-Pharmacology/Forum @.> Cc : Xavier Boulenc @.>; Author @.> Objet : Re: [Open-Systems-Pharmacology/Forum] Physiological fluid volume in the gut (#728)

Sorry, my misunderstanding...

You can change this via the fraction of stomach volume filled with liquid ... the parameter is called "Fractional steady state fill level": It can be found here: [image]https://ddec1-0-en-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fuser%2dimages.githubusercontent.com%2f25477643%2f117154525%2d3768bd00%2dadbc%2d11eb%2d9cce%2de62cb6b1e8d1.png&umid=47bf53b8-77f0-4f5d-8c64-6733832f9589&auth=670e6529b563b7dbb42ee90dda0d50ae13dc637b-613bfa7842c76f9d7b2b5615d9b34d5b5a74687b

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StephanSchaller commented 3 years ago

Hi Xavier,

no, this is the luminal volume of a "full" stomach. Liquid volume is "Fractional steady state fill level" multiplied with this "Volume" .. so around 50 ml? This would be the liquid volume in a fasted state. What the is added with the oral administration comes on top.

Best, Stephan

Boulenc commented 3 years ago

Hi Stephan,

My turn of misunderstanding ☺ Clear ; thank you for your help.

Regards.

Xavier.

De : esqlabs GmbH @.> Envoyé : mercredi 5 mai 2021 17:14 À : Open-Systems-Pharmacology/Forum @.> Cc : Xavier Boulenc @.>; Author @.> Objet : Re: [Open-Systems-Pharmacology/Forum] Physiological fluid volume in the gut (#728)

Hi Xavier,

no, this is the luminal volume of a "full" stomach. Liquid volume is "Fractional steady state fill level" multiplied with this "Volume" .. so around 50 ml? This would be the liquid volume in a fasted state. What the is added with the oral administration comes on top.

Best, Stephan

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