Open-Systems-Pharmacology / PK-Sim

PK-Sim® is a comprehensive software tool for whole-body physiologically based pharmacokinetic modeling
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Changing transpor direction in the expression is not applied in the simulation #2761

Closed PavelBal closed 11 months ago

PavelBal commented 1 year ago
  1. Add a transporter protein with direction "Efflux"
  2. Add a transport process using the new transporter protein to a molecule
  3. Create a simulation and send to MoBi:

image

  1. In the Expression Profile, change the direction of the transporter protein to "Influx". Simulation becomes "Red" and the comparison with building block correctly shows the difference in direction: image

  2. Right click on individual BB in the simulation and select "Update from BB"

  3. Send the updated simulation to MoBi -> Direction of the transport is still "Efflux":

image

PavelBal commented 1 year ago

Version 11.2

msevestre commented 11 months ago

It's because this is not seen as a structural change of the BB and the update will only be seen as a parameter update (which is quick update)