Metastatic (e.g. taken from a metastasis) and primary tumors are generally very different. Metastatic samples should be treated differently rather than together with primary samples.
Infer what TCGA variable governs whether the sample is metastatic or not and split them according to that variable into two before running the rest of the analysis.
Metastatic (e.g. taken from a metastasis) and primary tumors are generally very different. Metastatic samples should be treated differently rather than together with primary samples.
Infer what TCGA variable governs whether the sample is metastatic or not and split them according to that variable into two before running the rest of the analysis.