Lithium may be neuroprotective when taken with amphetamines and Lithium may decrease the hyperactive effects of amphetamines. Studies indicate this combination is safe.
Ago, Y., Tanaka, T., Kita, Y., Tokumoto, H., Takuma, K., & Matsuda, T. (2012). Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release. Neuropharmacology, 62(4), 1634–1639. https://doi.org/10.1016/j.neuropharm.2011.10.004
Gould, T. D., O’Donnell, K. C., Picchini, A. M., & Manji, H. K. (2007). Strain Differences in Lithium Attenuation of d-Amphetamine-Induced Hyperlocomotion: A Mouse Model for the Genetics of Clinical Response to Lithium. Neuropsychopharmacology, 32(6), 1321–1333. https://doi.org/10.1038/sj.npp.1301254
Zhou, Z., Wang, Y., Tan, H., Bharti, V., Che, Y., & Wang, J.-F. (2015). Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors. Neuroscience Letters, 603, 84–88. https://doi.org/10.1016/j.neulet.2015.07.027
Silverstone, P. H., Pukhovsky, A., & Rotzinger, S. (1998). Lithium does not attenuate the effects of d-amphetamine in healthy volunteers. Psychiatry Research, 79(3), 219–226. https://doi.org/10.1016/S0165-1781(98)00037-7
Lithium + Amphetamines
Lithium may be neuroprotective when taken with amphetamines and Lithium may decrease the hyperactive effects of amphetamines. Studies indicate this combination is safe.
Ago, Y., Tanaka, T., Kita, Y., Tokumoto, H., Takuma, K., & Matsuda, T. (2012). Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release. Neuropharmacology, 62(4), 1634–1639. https://doi.org/10.1016/j.neuropharm.2011.10.004
Gould, T. D., O’Donnell, K. C., Picchini, A. M., & Manji, H. K. (2007). Strain Differences in Lithium Attenuation of d-Amphetamine-Induced Hyperlocomotion: A Mouse Model for the Genetics of Clinical Response to Lithium. Neuropsychopharmacology, 32(6), 1321–1333. https://doi.org/10.1038/sj.npp.1301254
Zhou, Z., Wang, Y., Tan, H., Bharti, V., Che, Y., & Wang, J.-F. (2015). Chronic treatment with mood stabilizer lithium inhibits amphetamine-induced risk-taking manic-like behaviors. Neuroscience Letters, 603, 84–88. https://doi.org/10.1016/j.neulet.2015.07.027 Silverstone, P. H., Pukhovsky, A., & Rotzinger, S. (1998). Lithium does not attenuate the effects of d-amphetamine in healthy volunteers. Psychiatry Research, 79(3), 219–226. https://doi.org/10.1016/S0165-1781(98)00037-7
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