amplab / snap

Scalable Nucleotide Alignment Program -- a fast and accurate read aligner for high-throughput sequencing data
https://www.microsoft.com/en-us/research/project/snap/
Apache License 2.0
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Is SNAP effective for high error rate long read data such as Nanopore or others? #150

Closed jsonProgram closed 2 years ago

jsonProgram commented 2 years ago

hi Bolosky, I want to use SNAP to process nanopore data, I don't know if you have tested it?

Best, Json

bolosky commented 2 years ago

You can uncomment the definition of LONG_READS in Read.h and rebuild. You'll want to run it with parameters that let it search farther from the read (i.e,. higher values of -d).

That said, it's not designed or tested for nanopore reads, so you might not get the results you want. I recently tried it on some and it was at least OK at first blush, but that's not the same thing as really testing it.

From: jsonProgram @.> Sent: Tuesday, January 18, 2022 12:45 AM To: amplab/snap @.> Cc: Subscribed @.***> Subject: [amplab/snap] Is SNAP effective for high error rate long read data such as Nanopore or others? (Issue #150)

hi Bolosky, I want to use SNAP to process nanopore data, I don't know if you have tested it?

Best, Json

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jsonProgram commented 2 years ago

This information is very helpful for me, thank you!