Specification of autocorrelating to avoid sampling at the same time

[JeanUTHSC]

Hello Andrew,

Can I specify no autocorrelation to avoid sampling at the same time? According to the online guide, I tried the following script but got no success.

poped_db <- create.poped.database (strAutoCorrelationFile ="”),

I still have a lot of sampling points clustered at certain times.

Thank you, Jin

PKPD Modeler at AbbVie

[andrewhooker]

Hi

You need to specify an autocorrelation model to avoid samples at the same time.  Please see:

Nyberg, J., Höglund, R., Bergstrand, M., Karlsson, M. O., & Hooker, A. C. (2012). Serial correlation in optimal design for nonlinear mixed effects models. Journal of Pharmacokinetics and Pharmacodynamics, 39(3), 239–249. https://doi.org/10.1007/s10928-012-9245-5

For an explanation.

Best regards, Andrew

Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46 768 000 725 www.farmbio.uu.se/research/researchgroups/pharmacometrics/ On 6 Aug 2018, 05:06 +0200, jwang notifications@github.com, wrote:

Hello Andrew, Can I specify no autocorrelation to avoid sampling at the same time? According to the online guide, I tried the following script but got no success. poped_db <- create.poped.database (strAutoCorrelationFile ="”), I still have a lot of sampling points clustered at certain times. Thank you, Jin PKPD Modeler at AbbVie — You are receiving this because you are subscribed to this thread. Reply to this email directly, view it on GitHub, or mute the thread.

[JeanUTHSC]

Hi Andrew,

I've read that paper and understand the general principle. However, that paper didn't provide any popED script, which could not be found in popED documentations either. Do you mind offering a sample code illustrating how to use the autocorrelation model to avoid same time sampling?

Thank you, Jin