Genotype Representation Graph Library (GRGL)

GRGL can be used as a library in both C++ and Python. Support is currently limited to Linux and MacOS. It contains both an API (see docs) and a set of command-line tools.

Installing from pip

If you just want to use the tools (e.g., constructing GRG or converting tree-sequence to GRG) and the Python API then you can install via pip (from PyPi).

pip install pygrgl

This will use prebuilt packages for most modern Linux situations, and will build from source for MacOS. In order to build from source it will require CMake (at least v3.14), zlib development headers, and a clang or GCC compiler that supports C++11.

Building (C++ only)

Make sure you clone with git clone --recursive!

If you only intend to use GRGL from C++, you can just build it via CMake:

mkdir build && cd build
cmake .. -DCMAKE_BUILD_TYPE=Release
make -j4

See below to install the libraries to your system. It is recommended to install it to a custom location (prefix) since removing packages installed via make install is a pain otherwise. Example:

mkdir /path/to/grgl_installation/
mkdir build && cd build
cmake .. -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=/path/to/grgl_installation/
make -j4
make install
# There should now be bin/, lib/, etc., directories under /path/to/grgl_installation/

Building (Python)

Make sure you clone with git clone --recursive!

Requires Python 3.7 or newer to be installed (including development headers). It is recommended that you build/install in a virtual environment.

python3 -m venv /path/to/MyEnv
source /path/to/MyEnv/bin/activate
python setup.py bdist_wheel               # Compiles C++, builds a wheel in the dist/ directory
pip install --force-reinstall dist/*.whl  # Install from wheel

Build and installation should take at most a few minutes on the typical computer. For more details on build options, see DEVELOPING.md.

Building (Docker)

We've included a Dockerfile if you want to use GRGL in a container.

Example to build:

docker build . -t grgl:latest

Example to run, constructing a GRG from an example VCF file:

docker run -v $PWD:/working -it grgl:latest bash -c "cd /working && grg construct /working/test/inputs/msprime.example.vcf

Usage (Command line)

There is a command line tool that is mostly for file format conversion and performing common computations on the GRG. For more flexibility, use the Python or C++ APIs. After building and installing the Python version, run grg --help to see all the command options. Some examples are below.

Convert a tskit tree-sequence into a GRG. This creates my_arg_data.grg from my_arg_data.trees:

grg convert /path/to/my_arg_data.trees my_arg_data.grg

Load a GRG and emit some simple statistics about the GRG itself:

grg process stats my_arg_data.grg

To construct a GRG from a VCF file, use the grg construct command:

grg construct --parts 20 -j 1 path/to/foo.vcf

Construction for small datasets (such as those included as tests in this repository) should be very fast, a few minutes at most. Really large datasets (such as Biobank-scale) can take on the order of a day when using lots of threads (e.g., 70).

Usage (Python API)

See the provided jupyter notebooks and GettingStarted.md for more examples.

aprilweilab / grgl

readme