option to fragment interactions?

ay-lab / FitHiChIP

Statistically Significant loops from HiChIP data

MIT License

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option to fragment interactions? #100

Open hugch2020 opened 1 year ago

hugch2020 commented 1 year ago

Hi, I'm curious if it is possible to adapt FitHiChIP method for obtaining fragment interactions rather than binsize interactions, since the specific bin size would usually be smaller or larger than the length of enriched regions.

ay-lab commented 1 year ago

Hi. FitHiC can do this (https://genome.cshlp.org/content/24/6/999), it was actually designed exactly with this in mind. but given the overwhelming fraction of the people who use binned data, we did not implement this in Fithichip.