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ay-lab / fithic

Fit-Hi-C is a tool for assigning statistical confidence estimates to chromosomal contact maps produced by genome-wide genome architecture assays such as Hi-C.
MIT License
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Generate biasfile/KRnorm vector #34

Closed gheger11 closed 4 years ago

gheger11 commented 4 years ago

Hello, What would you recommend for generating the biasfile (i.e. KRnorm) from the Hi-C interaction matrix? All the tools I have found compute directly the KR normalized matrix, but as far as I understand, FitHiC requires the raw matrix and the bias vector. I have tried retrieving the bias vector from the diagonal balanced matrix, but I was wondering if there is a more straightforward approach you would recommend. Thanks!

gheger11 commented 4 years ago

Sorry, I just saw the utility for that right here. I close the issue.