broadinstitute / pilon

Pilon is an automated genome assembly improvement and variant detection tool
GNU General Public License v2.0
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Disable CCxGG motif skipping for bacteria / PCR amplified DNA ? #103

Open tseemann opened 4 years ago

tseemann commented 4 years ago
Pilon does not use the long reads to call the middle base of a CCxGG motif, 
as the ONT base calls can be confused by methylation.

If your library went through rounds of PCR, or you are sequencing an organism that doens't have CpG methylation, we don't want to skip those motifs in correction.

Can it be made a --skip-ccxgg switch?