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calico / basenji

Sequential regulatory activity predictions with deep convolutional neural networks.
Apache License 2.0
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Akita: result has no change after I deleted some sequences #122

Open gxygogogo opened 2 years ago

gxygogogo commented 2 years ago

Hi, Recently, I use the explore_model.ipynb to predict some sequences by GM12878. But after I deleted the CTCF site in the sequences, the result has no change. I wonder what causes this. @davek44

gfudenberg commented 2 years ago

hi, There are a broad range of behaviors that can happen from deletion of single, or even clusters of, CTCF sites-- this is true for model predictions as well as experimental data, e.g. http://genesdev.cshlp.org/content/31/22/2264.short https://pubmed.ncbi.nlm.nih.gov/31147463/