search

carmonalab / UCell

Gene set scoring for single-cell data
GNU General Public License v3.0
135 stars 16 forks source link

Ucell score to compare two gene lists for a given cluster. #28

Closed gk1610 closed 1 year ago

gk1610 commented 1 year ago

I want to identify whether a gene_list_A or gene_list_B is enriched in a given cluster using Ucell score? Can I just run anova test on Ucell scores from gene_list_A and gene_list_B to identify which gene list it is enriched for?

mass-a commented 1 year ago

Hello, it should be fine to compare distributions of scores using a statistical test. The test you suggest will indicate whether genes in set A have joint expression that differs from genes in set B. See also this other issue: #21.