Hepatic pit cell - Githubissues

Hey Alex,

The term 'hepatic pit cell' was added via term genie last December - defined as 
any lymphocyte that is part of a hepatic sinusoid.   Looking at the paper used 
as a reference - this is a farr too general defintion lacking important details.

I've changed it to: 

label "hepatic pit cell"^^string
definition "A large, granular, liver specific natural killer cell that adheres 
to the endothelial cells of the hepatic sinusoid." [PMID:9408963]
comment "Pit cells are named for the presence of large cytoplasmic granules 
that resemble pits (pips) of fruit."
SubClassOf: 
'natural killer cell'
has_part some 'secretory granule'
located_in some 'hepatic sinusoid'

The one thing I'd like to check is the change in classification to 'natural 
killer cell'.  This is certainly how it is described in the literature, but I'm 
a little worried that the implied molecular charactistics will not hold.  See 

http://www.copewithcytokines.de/cope.cgi?key=liver%20pit%20cells :  "Vermijlen 
et al (2004) have reported the results of microarray gene expression studies 
demonstrating that pit cells differ considerably in their gene expression 
patterns from blood-borne normal NK-killer cells or NK-cells after cell 
activation by IL2."

Do you think it is OK to stick with this classification?

- David

Original issue reported on code.google.com by dosu...@gmail.com on 8 Jan 2015 at 6:19

cmungall / cell-ontology-DO-NOT-USE

Hepatic pit cell #165