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cukarthik / IUDEHREstimationStudy-Old

Relative Risk of Cervical Neoplasms Associated with Copper and Levonorgestrel Secreting Intrauterine Devices: Real World Evidence from the OHDSI Network
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Improper negative controls #1

Open chandryou opened 5 years ago

chandryou commented 5 years ago

Levonorgestrel and Copper can have some systemic effect. We need to consider this more.

I think some of negative controls are inappropriate as below.

Concept Id Concept Code Name Vocabulary Reason
26662 111551000 Testicular hypofunction SNOMED It doesn't happen in women
432883 191611001 Recurrent major depressive episodes, moderate SNOMED Ref
438409 406506008 Attention deficit hyperactivity disorder SNOMED This disease is occurred in childeren
vojtechhuser commented 4 years ago

chandryou is probably right

mattspotnitz commented 4 years ago

I agree that testicular hypofunction is not appropriate and has been removed. However, I am not as convinced that depression or ADHD need to be removed from the negative control list. They are diagnoses that women could have antecedent to IUD placement and should have no effect on choice of device.

chandryou commented 4 years ago

@mattspotnitz It's on you, of course. I'm not sure ADHD or depression must be removed. But if I were you, I would remove them because they might be associated with these devices.

But, just to be clear

Negative controls are falsification endpoints. It doesn't matter whether they're associated with treatment assignment or not.

https://ohdsi.github.io/TheBookOfOhdsi/MethodValidity.html