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What's the meaning of Label？ #3

Closed Wangrui-berry closed 1 month ago

Wangrui-berry commented 1 month ago

Is the label about the response to Anti-HER2 treatment? And what dose the label in the excel (supplemental material) of "-1" (there is 0, 1, -1) represent?

tjwy commented 1 month ago

I'm also curious about the convert_label function. It seems that 1 represents a response, 0 represents no response, and -1 represents uncertainty. But, I'm puzzled by the judgment based on the cutoff values of OS and PFS.

czifan commented 1 month ago

Is the label about the response to Anti-HER2 treatment? And what dose the label in the excel (supplemental material) of "-1" (there is 0, 1, -1) represent?

Sorry for the late response.

To clarify:

  1. Label "0" represents non-responder, "1" represents responder, and "-1" indicates an indeterminate response.
  2. For treatment response prediction, only labels {0, 1} are used for analysis. However, for survival analysis, all data points, including "-1", are included in the analysis.

Hope this helps!

czifan commented 1 month ago

I'm also curious about the convert_label function. It seems that 1 represents a response, 0 represents no response, and -1 represents uncertainty. But, I'm puzzled by the judgment based on the cutoff values of OS and PFS.

  1. To clarify:

    • Label "0" represents non-responder, "1" represents responder, and "-1" indicates an indeterminate response.
    • For treatment response prediction, only labels {0, 1} are used for analysis. However, for survival analysis, all data points, including "-1", are included in the analysis.

  2. The OS and PFS cutoff values are determined based on the predicted probabilities for labels {0, 1} using the Youden index on the ROC curve.

Hope this helps!