d3b-center / ticket-tracker-OPC

A repo to generate and track tickets for ped OT
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Updated filter-mtp-tables module #511

Closed ewafula closed 1 year ago

ewafula commented 1 year ago

What analysis module should be updated and why?

Update filter-mtp-tables module to utilize targets and disease mapping files from the mtp-annotations module

What changes need to be made? Please provide enough detail for another participant to make the update.

0). Update 01-filter-mtp-tables-for-current-gencode.Rmd script 1). Utilize analyses/mtp-annotations/results/mtp-targets-mapping.tsv.gz and analyses/mtp-annotations/run-mtp-annotations.sh to filter Ensembl IDs and update EFO/MONDO respectively in MTP tables.
2). Include MTP gene-level and isoform-level methylation summary tables from the methylation-summary module 3). Inlcude upcoming DESeq long table 4). Remove 02-filter-mtp-tables-misc-updates.R script - no longer needed from v12 onwards 5). Exclude input/MTP_v11_InvalidENSG_20220831.txt - no longer needed from v12 onwards

What input data should be used? Which data were used in the version being updated?

MTP tables described in the filter-mtp-tables and methylation summary tables

When do you expect the revised analysis will be completed?

This sprint

Who will complete the updated analysis?

@atlas4213

jharenza commented 1 year ago

closed with https://github.com/PediatricOpenTargets/OpenPedCan-analysis/pull/349