search

dauparas / ProteinMPNN

Code for the ProteinMPNN paper
MIT License
934 stars 284 forks source link

Safety of generated sequences #50

Closed remybonnav closed 1 year ago

remybonnav commented 1 year ago

Hi, I was wondering if there is a way to have a safety filter in silico to be sure that the generated protein sequence with ProteinMPNN is "safe" to use. For example that it is not a toxin, a prion or a cell penetrating peptide? Do you think a simple blast would be sufficient? Are there better tools available (AI based or not) to safely design proteins sequences?

dauparas commented 1 year ago

Hello! I am not aware of any specific tools to evaluate the safety of designed protein sequences. A sequence homology search might be a good start.