Synthetic lethal screen analyses revealed that Rpn4, Ard1, Nat1 and Ber1 share a wide set of genetic interactions (Fig. 2). Our data therefore suggest that Ber1 may function in protein N-terminus acetylation and/or proteasome biogenesis. Since proteasome subunits are heavily N-acetylated (Csank et al. 2002), the role of Ber1 in proteasome assembly might be a secondary consequence of its role in protein modification. Thus, we suggest that Ber1 might be an accessory factor for the N-terminal acetyltransferase. We would however like to point out that with the currently available data this is only a working hypothesis.
The authors don't mention "microtubule based process" specifically, this is a phenotype from benomyl resistance.
Sequences with problematic annotation (ID + gene/protein name):
See above
Type of Issue: Erroneous source or erroneous propagation, or other issue
Erorneous annotation (phenotype)
Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).
Note that in mice this highly conserved gene is annotated to heme biosynthesis
and a new pombe paper implicates it in "isochore formation at the centromere"
Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere
PMID: 37237082
(I probably worn make a GO process from this paper)
marcfeuermann
commented
1 year ago
UniProtKB:Q9UH36 | SRRD | involved_in | GO:0007017 microtubule-based process | ECO:0000318 IBA | PMID:21873635 | PANTHER:PTN002007691 more... | 9606 Homo sapiens | GO_Central
Inference is from a single paper, and is really a phenotype
https://link.springer.com/article/10.1007/s00294-007-0169-3
This is the summary from the manuscript
Synthetic lethal screen analyses revealed that Rpn4, Ard1, Nat1 and Ber1 share a wide set of genetic interactions (Fig. 2). Our data therefore suggest that Ber1 may function in protein N-terminus acetylation and/or proteasome biogenesis. Since proteasome subunits are heavily N-acetylated (Csank et al. 2002), the role of Ber1 in proteasome assembly might be a secondary consequence of its role in protein modification. Thus, we suggest that Ber1 might be an accessory factor for the N-terminal acetyltransferase. We would however like to point out that with the currently available data this is only a working hypothesis.
The authors don't mention "microtubule based process" specifically, this is a phenotype from benomyl resistance.
Sequences with problematic annotation (ID + gene/protein name): See above
Type of Issue: Erroneous source or erroneous propagation, or other issue
Erorneous annotation (phenotype)
Note that in mice this highly conserved gene is annotated to heme biosynthesis and a new pombe paper implicates it in "isochore formation at the centromere"
Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere PMID: 37237082 (I probably worn make a GO process from this paper)
So whatever it is, it has pleiotropic effects