NTR: microtubule destabilizing activity / microtubule catastrophe promoting activity

Please provide as much information as you can:

Suggested term label: microtubule destabilizing activity / microtubule catastrophe promoting activity
Definition (free text) A protein-containing complex destabilizing activity that promotes microtubule catastrophe (transition from microtubule growth to microtubule shrinkage).
Reference, in format PMID:####### PMID:36435910
Gene product name and ID to be annotated to this term SPCC736.14 from pombe
Parent term(s)

GO:0140776 (protein-containing complex destabilizing activity)

Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

If the term "microtubule destabilizing activity" is used, microtubule severing activity could be added as a child.

Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

microtubule catastrophe inducing activity (if the label is "microtubule catastrophe promoting activity")

Cross-references
Any other information

I would like to request a more specific term (microtubule destabilizing activity), but a more generic one can be used instead (microtubule destabilizing activity). An equivalent activity exists for stabilisation

graph BT;
      http://purl.obolibrary.org/obo/GO_0140777["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140777>GO:0140777</a><br>protein-containing c<br>omplex stabilizing a<br>ctivity"]-->|is_a|http://purl.obolibrary.org/obo/GO_0003674["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0003674>GO:0003674</a><br>molecular_function"];
      http://purl.obolibrary.org/obo/GO_0140778["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140778>GO:0140778</a><br>microtubule stabiliz<br>ing activity</strong></u>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0140777["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140777>GO:0140777</a><br>protein-containing c<br>omplex stabilizing a<br>ctivity"];

The issue above has a good summary of microtubule dynamics. Certain pombe proteins, like dis1, klp5 and klp6 promote microtubule catastrophe. The exact molecular mechanism is unknown, but it is widely accepted that it involves the interactions of these proteins with the tubulin subunits that triggers catastrophe (through a TOG domain in the case of dis1, according to the reference above).

Not sure if this falls within the scope of MF, or it's more a BP. However, this is not just "positive regulation of microtubule depolymerisation", since this proteins induce the catastrophe themselves (even in vitro). Also, it's not very different from a microtubule severing activity, which already exists as a molecular function. I guess it's also a bit problematic that there is no "microtubule catastrophe" as biological process, and this only exists as a narrow synonym of microtubule depolymerisation.

graph BT;
      http://purl.obolibrary.org/obo/GO_0008568["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0008568>GO:0008568</a><br>microtubule severing<br> ATPase activity"]-->|is_a|http://purl.obolibrary.org/obo/GO_0140776["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140776>GO:0140776</a><br>protein-containing c<br>omplex destabilizing<br> activity</strong></u>"];
      http://purl.obolibrary.org/obo/GO_0140775["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140775>GO:0140775</a><br>actin filament debra<br>nching activity"]-->|is_a|http://purl.obolibrary.org/obo/GO_0140776["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140776>GO:0140776</a><br>protein-containing c<br>omplex destabilizing<br> activity</strong></u>"];
      http://purl.obolibrary.org/obo/GO_0140545["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140545>GO:0140545</a><br>ATP-dependent protei<br>n disaggregase activ<br>ity"]-->|is_a|http://purl.obolibrary.org/obo/GO_0140776["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140776>GO:0140776</a><br>protein-containing c<br>omplex destabilizing<br> activity</strong></u>"];
      http://purl.obolibrary.org/obo/GO_0003789["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0003789>GO:0003789</a><br>actin filament sever<br>ing activity"]-->|is_a|http://purl.obolibrary.org/obo/GO_0140776["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140776>GO:0140776</a><br>protein-containing c<br>omplex destabilizing<br> activity</strong></u>"];
      http://purl.obolibrary.org/obo/GO_0140776["<u><strong><a href=https://www.ebi.ac.uk/QuickGO/term/GO:0140776>GO:0140776</a><br>protein-containing c<br>omplex destabilizing<br> activity</strong></u>"]-->|is_a|http://purl.obolibrary.org/obo/GO_0003674["<a href=https://www.ebi.ac.uk/QuickGO/term/GO:0003674>GO:0003674</a><br>molecular_function"];

geneontology / go-ontology

NTR: microtubule destabilizing activity / microtubule catastrophe promoting activity #25274