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geneontology / go-ontology

Source ontology files for the Gene Ontology
http://geneontology.org/page/download-ontology
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GO:0008388 testosterone 15-alpha-hydroxylase activity with no cross reference #29066

Open raymond91125 opened 1 month ago

raymond91125 commented 1 month ago

GO:0008388 testosterone 15-alpha-hydroxylase activity lacks EC/RHEA cross references.

It has no publication references and 0 annotations. The only clue is a narrow synonym cytochrome P450 CYP2A4. PMID:10490589 indicated that CYP2A4 15-alpha-hydroxylates both testosterone and estrogens. Unirpot https://www.uniprot.org/uniprotkb/P15392/entry annotates it with EC:1.14.14.1, unspecific monooxygenase. There is no GO term for EC:1.14.14.1. EC:1.14.14.-, GO:0016712 oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor.

Perhaps GO:0008388 may be obsoleted with a replaced_by GO:0016712. However, the enzyme activity clearly is valid. Or we should create a new term for EC:1.14.14.1, unspecific monooxygenase.

pgaudet commented 2 days ago

@nnouspikel from RHEA will look into this one.