Pupylation is the process by which the small protein Pup is conjugated to proteins through its C-terminus to a lysine epsilon-amino group of the target. This modification, analogous to ubiquitination in eukaryotes, targets proteins for degradation by archaeal-type proteasomes in Mycobacterium tuberculosis and related Actinobacteria. This term is a perfect sibling to GO:0016925, and so it should have parents
GO:0032446 and GO:0043687
I suggest this formal definition:
The process by which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein.
Pupylation is the process by which the small protein Pup is conjugated to proteins through its C-terminus to a lysine epsilon-amino group of the target. This modification, analogous to ubiquitination in eukaryotes, targets proteins for degradation by archaeal-type proteasomes in Mycobacterium tuberculosis and related Actinobacteria. This term is a perfect sibling to GO:0016925, and so it should have parents GO:0032446 and GO:0043687
I suggest this formal definition:
The process by which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein.
See PMID: 18980670
Reported by: daniel_haft
Original Ticket: "geneontology/ontology-requests/5890":https://sourceforge.net/p/geneontology/ontology-requests/5890