children to GO:0009273: biogenesis of LAM & DIM/DIP layer

[gocentral]

Actinobacteria have two layers on top of the peptidoglycan-based cell wall. Understanding "GO:0009273 peptidoglycan-based cell wall biogenesis" to be applicable to them, two new specializations (PART_OF) of this entry are proposed:

"mycolate cell wall layer biogenesis" (actually lipoarabinomannan mycolate and trehalose dimycolate put together) and "DIM/DIP cell wall layer biogenesis" (verbosely (phenyl)phthiocerol/phthiodiolone/phthiotriol dimycocerosate/diphthioceranate).

Ref.: Daffie M and Lanielle MA (July 1988). "Distribution of phthiocerol diester, phenolic mycosides and related compounds in mycobacteria". J Gen Microbiol. 134 (7): 2049-55. PMID 3149973 Takayama K, Wang C, and Besra GS (January 2005). Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis. Clin Microbiol Rev. 18(1): 81–101. DOI: 10.1128/CMR.18.1.81-101.2005. PMCID: PMC544180. PMID 15653820

Reported by: rwst

Original Ticket: geneontology/ontology-requests/7255

[gocentral]

correction: NOT lipoarabinomannan mycolate BUT arabinogalactan mycolate.

You might also stand on the point that, since the mycolate layer is covalently bound to peptidoglycan, it's a proper part of it, so there isn't really a mycolate layer. OTOH, this does not apply to the DIM layer which BTW is also called PDIM in literature.

It all surely is complex...

Original comment by: rwst

[gocentral]

• assigned_to: nobody --> gomidori

Original comment by: mah11

[gocentral]

Hi,

I've added several terms to address this request such that it's compatible with existing terms:

Actinobacterium-type cell wall biogenesis GO:0071766 mycolic acid metabolic process GO:0071768 mycolic acid biosynthetic process GO:0071768 mycolate cell wall layer assembly GO:0071769 DIM/DIP cell wall layer assembly GO:0071770

Please let us know if you have any questions. m

Original comment by: mah11

[gocentral]

• status: open --> closed-accepted

Original comment by: mah11