frontonasal suture morphogenesis

[gocentral]

I would like to see “frontonasal suture morphogenesis” added to the GO ontology under the parent term " cranial suture morphogenesis" (GO:0060363). The definition could be "The process by which frontonasal bone sutures are generated and organized. Morphogenesis pertains to the creation of form.” An example can be found in PMID: 12416537.

Reported by: slaulederkind

Original Ticket: geneontology/ontology-requests/8493

[gocentral]

Definition of "frontonasal suture"? Currently none in FMA or MA.

random google: http://www.medilexicon.com/medicaldictionary.php?t=87216 "line of union of the frontal and of the two nasal bones"

The abstract suggests FN sutures are distinct from cranial sutures..

General observation: it doesn't make much sense for submitters to supply boilerplate like "The process by which frontonasal bone sutures are generated and organized. Morphogenesis pertains to the creation of form" as presumably the person adding the term in OE copies and pastes anyway.

Original comment by: cmungall

[gocentral]

• assigned_to: nobody --> paolaroncaglia

Original comment by: paolaroncaglia

[gocentral]

There are plenty of references in the biomedical literature to "craniofacial sutures" (PMID: 10521876). One would correctly conclude that "frontonasal suture" is a type of "craniofacial suture" or "facial suture". However, "craniofacial suture" is not found in the MA ontology, but "frontonasal suture" is found in the MA as a child term of "cranial suture" (There is no definition for "frontonasal suture" in the MA, but there are relatively few definitions in the entire MA). "abnormal frontonasal suture morphology" is a term in the MP ontology that is a child term of "abnormal cranial suture morphology". It would be consistent between the ontologies to put "frontonasal suture" as child term of "cranial suture". However, if we want to make a parent term of "craniofacial suture morphogenesis", followed by "cranial suture morphogenesis" and "facial suture morphogenesis" as it's children terms, that would be reasonable. The children terms of "facial suture morphogenesis" would include "internasal suture morphogenesis", "frontonasal suture morphogenesis" (synonym "nasofrontal suture morphogenesis"), and "interfrontal suture morphogenesis".

Original comment by: slaulederkind

[gocentral]

Hi Stan and Chris,

I've looked at quite a few pictures of head bones and sutures, and it seems to me that a reasonable way to solve the question would be to mirror the naming of bones, rather than of sutures themselves. That, at least, is unambiguous and universally accepted, and allows to discriminate accurately between what's cranial and what's facial.

So, based on the (human) cranial bones to be (8 bones): frontal, 2-parietal, occipital, 2-temporal, sphenoid and ethmoid, and on the facial bones to be (14 bones): 2-zygomatic, 2-maxillary, 2-palatine, 2-nasal, 2-lacrimal, vomer, 2-inferior conchae and mandible, I'd propose the following "suture ontology" which the morphogenesis terms would then follow:

craniofacial suture morphogenesis

• > frontonasal suture morhogenesis (syn. nasofrontal s.m.)
• > cranial suture morphogenesis
• • > coronal suture morphogenesis
• • > frontal suture morphogenesis (syn. interfrontal s.m.)
• • > lambdoid suture morphogenesis
• • > sagittal suture morphogenesis
• > facial suture morphogenesis
• • > nasal suture morphogenesis (syn. internasal s.m.)

For general references see see e.g. http://en.wikipedia.org/wiki/Head\_and\_neck\_anatomy\#Musculoskeletal\_system http://en.wikipedia.org/wiki/Cranial\_sutures

GO:0060363 cranial suture morphogenesis currently has a taxon constraint to Eukaryota. I would restrict the whole node (starting from craniofacial suture morphogenesis) to Vertebrata (not to Craniata, since at least some of the non-vertebrate Craniata have cartilage skulls). I'm assuming that cranial bones as listed above are the same in all Vertebrates, nut just mammals - I'll double check.

Let me know if you disagree with this proposal. Thanks, Paola

Original comment by: paolaroncaglia

[gocentral]

Paola, This looks good. If anybody needs terms for other sutures, they can be added as needed.

Original comment by: slaulederkind

[gocentral]

Hi Stan, these are done:

Added new terms: GO:0097094 craniofacial suture morphogenesis GO:0097095 frontonasal suture morphogenesis GO:0097096 facial suture morphogenesis GO:0097097 nasal suture morphogenesis (Exact synonym: internasal suture morphogenesis)

Edited def. of GO:0060363 cranial suture morphogenesis, and moved it under GO:0097094 craniofacial suture morphogenesis

Added exact synonym "interfrontal suture morphogenesis" to GO:0060364 frontal suture morphogenesis

As soon as GO:0097094 craniofacial suture morphogenesis is live, I'll add a taxon rule to it, to restrict it to Vertebrata. I'm leaving this SF item open so I don't forget.

Thanks, Paola

Original comment by: paolaroncaglia

[gocentral]

• status: open --> open-accepted

Original comment by: paolaroncaglia

[gocentral]

Added taxon constraint to restrict GO:0097094 craniofacial suture morphogenesis to Vertebrata.

Original comment by: paolaroncaglia

[gocentral]

• status: open-accepted --> closed-accepted

Original comment by: paolaroncaglia