endocrine hormone secretion

[gocentral]

I’d like to see the children of “endocrine hormone secretion” expanded. I’d like to see “steroid hormone secretion” (The regulated release of a steroid hormone into the circulatory system.) added as a child of “endocrine hormone secretion”. It could be a parent of: cortisol secretion, ecdysteroid secretion, progesterone secretion, and the new terms:

corticosteroid secretion (The regulated release of steroid hormones that are produced in the adrenal cortex),

androgen secretion (The regulated release of male sex hormones.)

estrogen secretion (The regulated release of female sex hormones.)

Children of corticosteroid secretion would be:
mineralocorticoid secretion (child: aldosterone secretion), glucocorticoid secretion (The regulated release of steroid hormones that promote gluconeogenesis and the formation of glycogen.) (children: cortisol secretion-synonym hydrocortisone secretion, corticosterone secretion).

Children of androgen secretion would be: androstenedione secretion, dehydroepiandosterone secretion-synonym DHEA secretion, testosterone secretion. PMID:12606499

Children of estrogen secretion would be: Estrone secretion PMID:8395854

Estradiol secretion PMID:21632818

Also, “regulation of …, positive regulation of …, and negative regulation of …” for all of the aforementioned terms would be good.

Reported by: slaulederkind

Original Ticket: geneontology/ontology-requests/8636

[gocentral]

• assigned_to: nobody --> rfoulger

Original comment by: rebeccafoulger

[gocentral]

Added terms in for the hormones that are already in GOCHE: steroid hormone secretion ; GO:0035929 corticosteroid secretion ; GO:0035930 mineralocorticoid secretion ; GO:0035931 aldosterone secretion ; GO:0035932 glucocorticoid secretion ; GO:0035933 corticosterone secretion ; GO:0035934 androgen secretion ; GO:0035935 testosterone secretion ; GO:0035936 estrogen secretion ; GO:0035937 estradiol secretion ; GO:0035938 (also added XPs in go_xp_chebi.obo)

Still to add (will need to add chemical to GOCHE (and XP file) at the same time): androstenedione secretion ; GO:NEW dehydroepiandosterone secretion ; GO:NEW estrone secretion ; GO:NEW

Have a couple of parentage queries relating to minor differences between CHEBI and GOCHE. I've put these in a new SF item: https://sourceforge.net/tracker/?func=detail&aid=3372369&group\_id=36855&atid=440764

Will do regulation terms via TG, when all terms are in, in correct position.

thanks Becky

Original comment by: rebeccafoulger

[gocentral]

Added the missing chemicals to goche, and the remaining terms to GO:

androstenedione secretion ; GO:0035941 dehydroepiandrosterone secretion ; GO:0035942 estrone secretion ; GO:0035943

Will add regulation terms via TermGenie, once the terms are live.

Original comment by: rebeccafoulger

[gocentral]

Here come the regulation terms:

id: GO:2000828 name: regulation of parathyroid hormone secretion

id: GO:2000829 name: negative regulation of parathyroid hormone secretion

id: GO:2000830 name: positive regulation of parathyroid hormone secretion

id: GO:2000831 name: regulation of steroid hormone secretion

id: GO:2000832 name: negative regulation of steroid hormone secretion

id: GO:2000833 name: positive regulation of steroid hormone secretion

id: GO:2000834 name: regulation of androgen secretion

id: GO:2000835 name: negative regulation of androgen secretion

id: GO:2000836 name: positive regulation of androgen secretion

id: GO:2000837 name: regulation of androstenedione secretion

id: GO:2000838 name: negative regulation of androstenedione secretion

id: GO:2000839 name: positive regulation of androstenedione secretion

id: GO:2000840 name: regulation of dehydroepiandrosterone secretion

id: GO:2000841 name: negative regulation of dehydroepiandrosterone secretion

id: GO:2000842 name: positive regulation of dehydroepiandrosterone secretion

id: GO:2000843 name: regulation of testosterone secretion

id: GO:2000844 name: negative regulation of testosterone secretion

id: GO:2000845 name: positive regulation of testosterone secretion

id: GO:2000846 name: regulation of corticosteroid hormone secretion

id: GO:2000847 name: negative regulation of corticosteroid hormone secretion

id: GO:2000848 name: positive regulation of corticosteroid hormone secretion

id: GO:2000849 name: regulation of glucocorticoid secretion

id: GO:2000850 name: negative regulation of glucocorticoid secretion

id: GO:2000851 name: positive regulation of glucocorticoid secretion

id: GO:2000852 name: regulation of corticosterone secretion

id: GO:2000853 name: negative regulation of corticosterone secretion

id: GO:2000854 name: positive regulation of corticosterone secretion

id: GO:2000855 name: regulation of mineralocorticoid secretion

id: GO:2000856 name: negative regulation of mineralocorticoid secretion

id: GO:2000857 name: positive regulation of mineralocorticoid secretion

id: GO:2000858 name: regulation of aldosterone secretion

id: GO:2000859 name: negative regulation of aldosterone secretion

id: GO:2000860 name: positive regulation of aldosterone secretion

id: GO:2000861 name: regulation of estrogen secretion

id: GO:2000862 name: negative regulation of estrogen secretion

id: GO:2000863 name: positive regulation of estrogen secretion

id: GO:2000864 name: regulation of estradiol secretion

id: GO:2000865 name: negative regulation of estradiol secretion

id: GO:2000866 name: positive regulation of estradiol secretion

id: GO:2000867 name: regulation of estrone secretion

id: GO:2000868 name: negative regulation of estrone secretion

id: GO:2000869 name: positive regulation of estrone secretion

id: GO:2000870 name: regulation of progesterone secretion

id: GO:2000871 name: negative regulation of progesterone secretion

id: GO:2000872 name: positive regulation of progesterone secretion

Hopefully I've got them all- let me know if not. Becky

Original comment by: rebeccafoulger

[gocentral]

• status: open --> closed-accepted

Original comment by: rebeccafoulger

[gocentral]

Hi Becky, Thanks for adding all those terms. However, the cortisol terms are missing. Thanks, Stan

Original comment by: slaulederkind

[gocentral]

• status: closed-accepted --> open-accepted

Original comment by: slaulederkind

[gocentral]

Hi Stan,

The cortisol terms were there already:

cortisol secretion ; GO:0043400 regulation of cortisol secretion ; GO:0051462 negative regulation of cortisol secretion ; GO:0051463 positive regulation of cortisol secretion ; GO:0051464

So I just added 'hydrocortisone secretion' as a synonym to GO:0043400.

thanks Becky

Original comment by: rebeccafoulger

[gocentral]

Thanks, Becky. Somehow I missed the cortisol terms. Stan

Original comment by: slaulederkind

[gocentral]

• status: open-accepted --> closed-accepted

Original comment by: rebeccafoulger