Dears,
First, thanks a lot for this wonderful package that helps me to analyse and understand more about my scRNA data.
I have a question regarding the CellChatDB, it contains an interaction table that contains ligands and multimeric receptors. For example, the contents of the ligand is 1 value like "TGFB1" and the contents of the receptor are multimeric receptors for example: ACVR1B_TGFbR2.
If I would like to use the CellChatDB to analyze the interaction between ligand and receptors in bulk array data within different samples, is it okay to separate the multimeric receptors? I mean to make ligand "TGFB1" corresponding to "ACVR1B" and in another row that ligand "TGFB1" corresponding to receptor "TGFbR2"
@ManarRashad While it is OK to separate the multimeric receptors like the way in other tools, we think it is more accurate when using multimeric receptors.
Dears, First, thanks a lot for this wonderful package that helps me to analyse and understand more about my scRNA data. I have a question regarding the CellChatDB, it contains an interaction table that contains ligands and multimeric receptors. For example, the contents of the ligand is 1 value like "TGFB1" and the contents of the receptor are multimeric receptors for example: ACVR1B_TGFbR2.
If I would like to use the CellChatDB to analyze the interaction between ligand and receptors in bulk array data within different samples, is it okay to separate the multimeric receptors? I mean to make ligand "TGFB1" corresponding to "ACVR1B" and in another row that ligand "TGFB1" corresponding to receptor "TGFbR2"
Please help Thanks in advance