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lhqxinghun / scKTLD

A python package for identifying TAD-like domains on single-cell Hi-C data
MIT License
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Can scKTLD be used in bulk Hi-C data? #1

Open dangdachang opened 1 month ago

dangdachang commented 1 month ago

Hello, scKTLD seems to be a powerful tool to find TAD-like domains and reconstruct the contact matrix of single-cell Hi-C data. I wonder whether scKTLD can be used in traditional bulk Hi-C data to find TAD, or in bulk Hi-C data with insufficient sequencing reads. If yes, do the parameters need to be adjusted?

I look forward to hearing from you, thank you!

lhqxinghun commented 2 weeks ago

Yes，scKTLD can be used for bulk Hi-C data with insufficient sequencing reads. You can use the optimal parameters reported in our paper, and the parameters can be further optimized for your own dataset for better performance.

dangdachang commented 2 weeks ago

Thanks for your reply. I can use scKTLD now.