meyer-lab / tHMM

A general Python framework for using hidden Markov models on binary trees or cell lineage trees.
https://asmlab.org
MIT License
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Analyse #881

Closed Farnazmdi closed 2 years ago

Farnazmdi commented 2 years ago

To analyze the MCF10A data.

codecov[bot] commented 2 years ago

Codecov Report

Merging #881 (112cabb) into master (c66eff4) will decrease coverage by 2.34%. The diff coverage is 50.00%.

Impacted file tree graph

@@            Coverage Diff             @@
##           master     #881      +/-   ##
==========================================
- Coverage   76.11%   73.76%   -2.35%     
==========================================
  Files          26       26              
  Lines        2106     2150      +44     
==========================================
- Hits         1603     1586      -17     
- Misses        503      564      +61     
Flag Coverage Δ
unittests 73.76% <50.00%> (-2.35%) :arrow_down:

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Impacted Files Coverage Δ
lineage/BaumWelch.py 72.89% <0.00%> (-6.70%) :arrow_down:
lineage/Lineage_collections.py 0.00% <0.00%> (ø)
lineage/plotTree.py 0.00% <0.00%> (ø)
lineage/states/StateDistributionGamma.py 87.14% <0.00%> (-4.59%) :arrow_down:
lineage/tHMM.py 96.15% <25.00%> (-1.89%) :arrow_down:
lineage/states/stateCommon.py 94.44% <81.81%> (-1.02%) :arrow_down:
lineage/import_lineage.py 96.37% <96.36%> (-1.13%) :arrow_down:
lineage/tests/test_import_lineage.py 100.00% <100.00%> (ø)

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Farnazmdi commented 2 years ago

This is almost done. I moved the 3 figures (BIC, analysis of HGF, and analysis of OSM) to the dropbox folder we have for resubmission in the figures folder, but they need a bit of attention from JC to look better. I will have to read about HGF and OSM effects on MCF10A to explain the results. I will do that tomorrow.

aarmey commented 2 years ago

Since the inter-treatment constraint is removed, you can just analyze all the treatments as one batch.

Farnazmdi commented 2 years ago

No sorry, not ready... When you say analyze all in one batch, do you mean just one BIC figure for all three conditions? Then we will let the states kind of separate the treatments?

aarmey commented 2 years ago

Aren't there four treatments? (PBS, EGF, HGF, OSM)

Yes, that's what I mean.

Farnazmdi commented 2 years ago

I am on it. I kept egf away, it was throwing an error.. but will try to resolve it.

Farnazmdi commented 2 years ago

It is ready for review. I ran the BIC a couple of times, all the time 6 states was optimal. image image

Farnazmdi commented 2 years ago

image The new plot. needs a bit of edit in AI though.

Farnazmdi commented 2 years ago

Was there anything else you wanted me to edit in this branch? @aarmey