mgijax / mammalian-phenotype-ontology

Standard terms for annotating mammalian phenotypic data
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MPD blood level terms #4034

Closed sbello closed 4 weeks ago

sbello commented 1 month ago

From Molly: Requested term: abnormal blood secretin amount Proposed parent: abnormal circulating hormone level MP:0005418 Draft definition: any anomaly in the blood concentration of this polypeptide hormone, secreted by the wall of the upper part of the small intestine (duodenum), that regulates gastric acid secretion and water homeostasis throughout the body.

Requested term: abnormal blood pancreatic polypeptide amount Proposed parent: abnormal circulating hormone level MP:0005418 Draft definition: any anomaly in the blood concentration of this polypeptide hormone, secreted by the endocrine pancreas, that regulates pancreatic secretion activities, liver glycogen storage, and gastrointestinal secretion.

Requested term: abnormal blood peptide YY (tyrosine tyrosine) amount Proposed parent: abnormal circulating hormone level MP:0005418 Draft definition: any anomaly in the blood concentration of this peptide hormone, released from cells in the ileum and colon in response to feeding, that plays a role in appetite regulation and obesity.

Requested term: abnormal blood resistin amount Proposed parent: abnormal circulating hormone level MP:0005418 Draft definition: any anomaly in the blood concentration of this cysteine-rich peptide hormone, derived from adipose tissue, that is implicated in the modulation of insulin activity, energy, glucose, and lipid homeostasis.

sbello commented 1 month ago

Modifications

terms should use the 'abnormal circulating X level' with Molly's labels as synonyms

secretin, pancreatic polypeptide - no existing annotations for this

resistin - see J:212299, J:256501, J:129967

peptide YY - see J:256501

sbello commented 1 month ago

pancreatic polypeptide - already exists MP:0008459

sbello commented 1 month ago

Terms are in but there is an issue with the eqs

sbello commented 1 month ago

Ticket to get the PRO terms added to the slim so we can create the eqs https://github.com/obophenotype/pro_obo_slim/issues/46

sbello commented 4 weeks ago

eqs added, imports refreshed and all is good