sbello
commented
2 years ago Rather than changing the definitions or placement we may need to change the labels of these terms. The definitions fit for the placement of the terms. Looking at annotations we may need the non-cell death terms
Need to review text definitions and placement of cellular sensitivity terms.
is_a MP:0000313 ! abnormal cell death [DEF: "any anomaly in the cessation of function at the cellular level"] > is_a MP:0008942 ! abnormal induced cell death [DEF: "anomaly in the response to an agent that induces cessation of function at the cellular level"] > is_a MP:0008943 ! increased sensitivity to induced cell death [DEF: "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level"] > is_a MP:0004227 ! increased cellular sensitivity to ionizing radiation [DEF: "increased incidence of cell death following exposure to high levels of ionizing radiation"] > is_a MP:0002007 ! increased cellular sensitivity to gamma-irradiation *** [DEF: "increased incidence of cell death following exposure to high levels of gamma-irradiation"] > > > >> c- The response to radiation is not always death. Where did this definition come from? > >> > >> P > >> > >> Sent from my iPhone > >> >> >>> I made the following changes to better leverage GO and also to better mirror the textual definitions and MP hierarchy: >> >>> >> >>> [Term] >> >>> id: MP:0002007 ! increased cellular sensitivity to gamma-irradiation >> >>> -intersection_of: PATO:0001549 ! increased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010332 ! response to gamma radiation >> >>> +intersection_of: PATO:0000912 ! increased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from GO:0071480 ! cellular response to gamma radiation >> >>> >> >>> >> >>> [Term] >> >>> id: MP:0002879 ! increased cellular sensitivity to X-ray irradiation >> >>> -intersection_of: PATO:0001549 ! increased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010165 ! response to X-ray >> >>> +intersection_of: PATO:0000912 ! increased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from GO:0071480 ! cellular response to gamma radiation >> >>> >> >>> >> >>> [Term] >> >>> id: MP:0003207 ! decreased cellular sensitivity to gamma-irradiation >> >>> -intersection_of: PATO:0001550 ! decreased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010332 ! response to gamma radiation >> >>> +intersection_of: PATO:0000911 ! decreased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from GO:0071480 ! cellular response to gamma radiation >> >>> >> >>> >> >>> [Term] >> >>> id: MP:0004227 ! increased cellular sensitivity to ionizing radiation >> >>> -intersection_of: PATO:0001549 ! increased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010212 ! response to ionizing radiation >> >>> +intersection_of: PATO:0000912 ! increased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from GO:0071479 ! cellular response to ionizing radiation >> >>> >> >>> [Term] >> >>> id: MP:0004228 ! decreased cellular sensitivity to ionizing radiation >> >>> -intersection_of: PATO:0001550 ! decreased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010212 ! response to ionizing radiation >> >>> +intersection_of: PATO:0000911 ! decreased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from GO:0071479 ! cellular response to ionizing radiation >> >>> >> >>> [Term] >> >>> id: MP:0004587 ! decreased cellular sensitivity to X-ray irradiation >> >>> -intersection_of: PATO:0001550 ! decreased sensitivity >> >>> -intersection_of: inheres_in GO:0005623 ! cell >> >>> -intersection_of: towards GO:0010165 ! response to X-ray >> >>> +intersection_of: PATO:0000911 ! decreased rate >> >>> +intersection_of: inheres_in GO:0008219 ! cell death >> >>> +intersection_of: results_from MP:0002879 ! increased cellular sensitivity to X-ray irradiation
Reported by: cindyJax
Original Ticket: obo/mammalian-phenotype-requests/936