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monarch-initiative / mckb

Monarch Cancer Knowledge Base
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curate drug response phenotypes #6

Open kshefchek opened 9 years ago

kshefchek commented 9 years ago

We need to map the following terms the NCI thesaurus or the appropriate ontology, or create new ones as needed:

decreased sensitivity detrimental effect increased benefit no response no sensitivity reduced sensitivity resistance response sensitivity

From the synapse wiki for the dataset:

"In order to give unbiased and more detailed information with regard to the magnitude of the biomarker-related drug effects, we expanded the typical binary classification of responsive and resistant. In the advanced clinical setting, effect is outlined as responsive, resistant or not responsive (when an expected responsive effect is not observed). In preclinical models, biomarker-drug associations are graded as sensitive, reduced sensitivity or resistant."

nlwashington commented 9 years ago

@cmungall and @mbrush to discuss

cmungall commented 9 years ago

What kind of thing do these relations connect? (pointer to dipper job is fine)