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obophenotype / cell-ontology

An ontology of cell types
https://obophenotype.github.io/cell-ontology/
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[NTR] Lamina propria fibroblast (S1) #2565

Open JABelfiore opened 1 week ago

JABelfiore commented 1 week ago

Please check that the term does not already exist by using the ontology search tool OLS: https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label Lamina propria fibroblast (S1)

Synonyms (add reference(s), please) S1 fibroblast [PMID:30270042]

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX) A fibroblast is located in the lamina propria of the intestinal mucosa, particularly in the small intestine. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is positioned adjacent to myofibroblasts surrounding colonic crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin[PMID:36639348][PMID:36251739].

Extended: Plays a critical role in maintaining intestinal homeostasis, supporting epithelial growth and repair, and contributing to immune responses. Derived from Gli1-expressing precursors present in embryonic day 12.5 intestine. Part of a diverse network of fibroblasts with region-specific functions in the small and large intestine. May contribute to the stem cell niche by secreting factors that influence epithelial cell behavior[PMID:36639348][PMID:36251739].

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Fibroblast

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Lamina propria of intestinal mucosa

Your ORCID https://orcid.org/0009-0005-7919-4905

Additional notes or concerns

dosumis commented 1 week ago

Add in links to GO via capable of. e.g. extracellular matrix constituent secretion http://purl.obolibrary.org/obo/GO_0070278