pnrobinson
commented
1 month ago Adding new term:
- ID: HP:6001104
- label: Abnormal vestibulo-spinal reflex
- parents: Abnormal vestibular function (HP:0001751)
- pmid: PMID:29081426|PMID:38178884
- def: An abnormality of the vestibulospinal (VS) reflexes, which contribute to the control of postural orientation. In this task, they continuously collaborate with reflexes elicited by stimulation of visual and somatosensory receptors. Labyrinthine receptors are sensitive to modifications (i) of the head position with respect to the earth vertical or (ii) of the angular/linear velocity of head motion in space. This information can be used to monitor deviations from the maintained body position.
- comment:
- orcid: orcid:0000-0002-0736-9199
- github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/10638
- synonyms:
Preferred term label:
Synonyms Impaired vestibulospinal reflexes
Definition (free text, please give PubMed ID) Manzoni, D. (2009). Vestibulo-spinal Reflexes. In: Binder, M.D., Hirokawa, N., Windhorst, U. (eds) Encyclopedia of Neuroscience. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29678-2_6315 : The vestibulospinal (VS) reflexes are changes in the activity of body muscles induced by movements of the head in space that stimulate and aimed at stabilizing. Characteristics : Functions The VS reflexes contribute to the control of postural orientation. In this task, they continuously collaborate with reflexes elicited by stimulation of visual and somatosensory receptors. Labyrinthine receptors are sensitive to modifications (i) of the head position with respect to the earth vertical or (ii) of the angular/linear velocity of head motion in space. This information can be used to monitor deviations from the maintained body position.
PMID: 29081426 These symptoms in BVP are caused by the sensory vestibular deficit leading to impaired vestibulo-spinal reflexes leading to higher body sway and broad-based gait.
PMID: 38178884 Two of the main physical symptoms of BVP are movement induced blurred vision (oscillopsia) and unsteadiness when walking or standing which often worsens on uneven ground or in darkness. These symptoms are primarily due to impaired vestibular-ocular and vestibular-spinal reflexes.
Parent term (use hpo.jax.org/app) Abnormal vestibular function HP:0001751
Diseases characterized by this term ? (e.g. Orphanet or OMIM number) Idiopathic bilateral vestibulopathy ORPHA:171684
Your nano-attribution (ORCID) 0009-0005-6714-5727