NTR: Recombinant JCV-Virus protein 1 antibody titer high in CSF (Lab: serology & immunological tests)

obophenotype / human-phenotype-ontology

Ontology for the description of human clinical features

http://obophenotype.github.io/human-phenotype-ontology/

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NTR: Recombinant JCV-Virus protein 1 antibody titer high in CSF (Lab: serology & immunological tests) #8743

Closed pnrobinson closed 2 months ago

pnrobinson commented 1 year ago

New term request Recombinant JCV-Virus protein 1 antibody titer high in CSF (samant_110123155513): VP1; cerebrospinal fluid; Creutzfeldt-Jakob disease; Jakob -Creutzfeldt disease

pnrobinson commented 7 months ago

@MickeySegal is it this virus: https://de.wikipedia.org/wiki/JC-Virus Why "recombinant"?

MickeySegal commented 7 months ago

The recombinant part should be deleted - it was probably how the antibodies were obtained, but that is not important.

The Jakob Creutzfeldt part in our description is an error. JC stands for John Cunningham.

I changed our finding name to JCV-VP1 because otherwise it seemed like the V was listed twice redundantly, and explained the VP1 as virus protein 1 in the synonyms.

pnrobinson commented 2 months ago

@MickeySegal Adding new term:

ID: HP:6000928
label: Positive CSF JC-virus antibody positivity
parents: Positive CSF pathogen-specific antibody positivity (HP:0430139)
pmid:
def: The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of JC-virus (also known as JC-polyomavirus and John Cunningham virus).
comment:
orcid: orcid:0000-0002-0736-9199
github ID: https://github.com/obophenotype/human-phenotype-ontology/issues/8743
synonyms: Positive CSF JC-polyomavirus antibody positivity(NONE)