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theislab / ncem

Learning cell communication from spatial graphs of cells
https://ncem.readthedocs.io/
BSD 3-Clause "New" or "Revised" License
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Differential interaction #98

Closed wangjiawen2013 closed 2 years ago

wangjiawen2013 commented 2 years ago

Hi, Does ncem support differential analysis between two conditions (healthy and disease samples)?

wangjiawen2013 commented 2 years ago

Besides, can ncem be used to analyze both scRNA-seq and spatial transcriptome or only spatial transcriptome ?

AnnaChristina commented 2 years ago

Hi @wangjiawen2013,

thanks for your questions.

Does ncem support differential analysis between two conditions (healthy and disease samples)?

NCEM can be used separately on conditions by first identifying type couplings in the healthy samples and then in the diseased ones.

Besides, can ncem be used to analyze both scRNA-seq and spatial transcriptome or only spatial transcriptome ?

NCEM is designed for spatial transcriptomics data. It can, however, be used for imputed scRNA-seq data.

I hope this answers your questions. I am closing this issue, but please feel free to open it again in case of further comments. Thanks!