Open ppjeep opened 6 years ago
I agree that synonymous variants may not be considered lof. For some of our own work, we group variants that are nonsynonymous, stop_gain or splice [see e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709146/] The choice of the annotation used to group variant is more of a personal taste, no right or wrong.