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See the discussion in https://github.com/lme4/lme4/issues/744 regarding `PRIMA.bobyqa` in linear mixed models. It may be even more useful to switch to `PRIMA.bobyqa` for GLMM optimization because tha…
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We need a structure to deal with two related issues:
1- Some sites or plots are nested within others. For example, `Wind River Canopy Crane` is within `Wind River CTFS-ForestGEO plot`.
2- In some c…
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# POND/Off - Comparing Alzheimer's progression models
## Project Leader: Cameron Shand [c.shand@ucl.ac.uk](mailto:c.shand@ucl.ac.uk)
## 📝 Description:
**Are Alzheimer's disease progression mode…
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I was asked today about how to use `nlmixr2` by a statistician I'm working with. The request was two-fold: To help learn nonlinear mixed effects modeling (very broad) and to learn how to use nlmixr2…
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Dear Joshua,
Thank you very much for developing the *brmsmargins* package. I am trying to understand a paragraph included in the help file for the *brmsmargins()* function and would appreciate an…
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The `anova` method for `merMod` objects always refits a LMM with `REML = TRUE` via `refitML.merMod`. This may lead to undesired consequences, as `refitML.merMod` does (a) neither inherit the optimizat…
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@strengejacke Thanks to your work on ICC, we could start thinking about its reporting. I think this information has its place, when applicable, in the full reports (fulltext and fulltable). Below are …
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It would be nice to be able to support general covariance matrices (or, you know, at least a small number of popular presets) for the errors in Gaussian models -- commonly called the R matrix in the m…
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Here I will collect text & materials I need for a JOSS submition