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When working on [this](https://github.com/nlmixrdevelopment/nlmixr/issues/181), I found something quite strange.
Let's take the most basic example from the vignette:
```
library(nlmixr)
one.…
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NONMEM has a very nice format to define steady-state dosing.
We should at least support this at the model / prediction level.
This will allow us to find the dose that puts the patient within targe…
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i was using monolix suite 2018R2 and it was working fine
then i tired to install Rsmlx last day
and since then my monolix verson cant run new project anymore
and keep on giving me this error
#pars…
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Hi,
I am trying to fit two separate observations (glc and ins) in the same individual (DVID= 1 and 2) within nlmixR. The first indiviudal for glucose and insulin are:
`
ID | AMT | TIME | DV | EVI…
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Matt,
how would one signify the current time point in the solver if the value of the time point itself is used in an equation within the model in and ODE model using nlmixr? I am looking for the FO…
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was wondering if there is a way in the model definition to use internal variables, especially `time` (either discrete or continuous time, i.e. TIME or T in NONMEM), and the event type at a specific ti…
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I'm a beginner as R user. And excuse my poor English.
Now I'd like to validate the result by nlmixr and SAS, using theophylline data.
So, I'm trying the description "pred = dose * ke * ka * (exp(-ke…
51sep updated
5 years ago
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Hello,
There are a couple of questions I had while coding a model using RxODE.
1.) How to account for weight/BSA based dosing in add.dosing?
eg, if I want to simulate 20 mg/m2 dose IV infusion.…
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Hi,
In the function sim_data(), the parameter theta should be given such as cl, ka and ke. How to estimate these values? Dose the linear regression be a good tool for calculation? Need your comments.…
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Hey Ron,
Would you mind checking to see if your results are mirroring mine:
```
library(ggplot2)
library(PKPDsim)
library(microbenchmark)
p