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Hello Members,
Can any one share the relative expression of CYP3A4 enzyme in beagle dog, iam trying to build PBPK model of a compound in beagle dog
Is there any link from where we can download the…
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Hello, I'm a beginner to PBPK and I have a question. In PKSim, some drug metabolic and transport processes under Michaelis-Menten type use units of volume such as μmol/l/min for Vmax, however, I found…
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Hi,
I am working on a project where I have PK data from IV and PO administrations across 4 pre-clinical species (mouse, rat, beagle, monkey). However, I'm not able to capture the shape of the PK pr…
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Hi folks,
I performed the sensitivity analysis on CL/F and V for a pediatric PBPK model (for a small molecule) to find important input parameters that affect CL prediction.
As a result, fat and m…
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Dear all,
I got a question from a customer, and I am not sure if it makes sense. He asked if it is possible to reduce the compartmental absorption model implemented in PKSim to a first order absorpti…
RKasp updated
5 years ago
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I am using Ciprofloxacin data to simulate PK profile for 500 mg dose. In the Tutoria…
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Can we replace the "simple.pkml" by, e.g. "S1" from the test suite? This simple model is so simple that it even does not produce any results when simulating, and writing examples with it turns out to …
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Hi All,
I was wondering whether it is possible to fit standard compartmental models within PK-Sim.
Many thanks for your feedback.
Kind regards,
Francesca
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Hi All,
I have a hydrophilic small molecule (logP ~ -2, pKa (basic) = 7.5) that I am trying to fit in mice, with goal of extrapolating tissue concentrations to humans. The drug has negligible tissue…
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Hello,
I'm new to using Pk-sim, just practicing with a basic PBPK model for clofazimine, which his highly lipophilic drug that accumulate mainly in adipose and fatty tissues mainly metabolized by l…