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Hi All,
I was wondering whether it is possible to fit standard compartmental models within PK-Sim.
Many thanks for your feedback.
Kind regards,
Francesca
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Hi All,
I have a hydrophilic small molecule (logP ~ -2, pKa (basic) = 7.5) that I am trying to fit in mice, with goal of extrapolating tissue concentrations to humans. The drug has negligible tissue…
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Hello,
I'm new to using Pk-sim, just practicing with a basic PBPK model for clofazimine, which his highly lipophilic drug that accumulate mainly in adipose and fatty tissues mainly metabolized by l…
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How to predict curve (AUC) by dissolution data in ivtro ???
please every expert !
thank you
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Dear all,
here is a more general question regarding CYP abundance in PK-sim.
Having a look at the total intestinal CYP abundance for 2C19 it seems to be quite high. Actually 2C19 expression seems t…
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Can you please help me not shoot myself in the foot (or at least bandage it quickly after I do so)? :)
On EVID=3 rows I just set CMT=0. When I did that, I got the error:
```r
sim_result %
+ …
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Hello,
I need help in modifying a PBPK model in MoBi in order to include a step of hydrolysis of conjugated metabolite via gut flora glocurinidase enzymes to release the parent compound and its sub…
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Hello,
I'm trying to replicate a prior PBPK model of Digoxin.
The publication mentions ATP1A2 Koff and Kd values and P-gp Km and Kcat.
In the compounds- distribution- specific binding- protein…
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# Release Notes for the Open Systems Pharmacology Software Suite 8
## Important note – read BEFORE installation
[User Template Database migration from 7.3 (and below) to 7.4 and above](https://git…
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Hello all,
I have attached data which iam using for fitting, if you can help it will be of great help.
I tried optimising the lipophillicity from the LogP value i have, if i increase the value to >3…