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Dear OSP forum,
Let me explain the clinical scenario here.
We came across an obese patient with a certain infection. We're trying to understand how to dose this patient. The patient is around 140…
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I am trying to build a PBPK model for Meropenem. I was following the example (Ciprofloxacin) to develop this model.
I do not know how to implement the 70% renal clearance factor into the compound.
P…
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Hi everybody,
According to the Pk-Sim manual the gain in solubility by diferences in pH is described by the Henderson-Hasselbalch equation.
I assume it refers to:
LogS = LogSo + Log (1 + 10^(pKb-…
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Dear All,
I am just wondering why changing the gastric pH in the Itraconazole model -PK-Sim template model- doesn't show any changes in the plasma profile curve or the PK parameters, although this dr…
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Hello,
Is there a way to switch to blood flow limited/perfusion limited models for drug kinetics in PK-Sim for small molecules model? By default it uses permeability limited type of model when no l…
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Dear all
I've been testing PKSim for the last months and becoming a fan!
For simulating clinical trials, however, it would be interesting if inter-occasion (or intra-subject) variability could be se…
nmens updated
6 years ago
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If you have 30% bound, will the administered dose be used as input as 100% or reduced by 30%? I cannot see the differential equations in each organ compartment to help me understand that. Thank you ve…
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Consider my example from #46 .
The described model is loaded into R and no parameters are initialized:
```
library(MoBiToolboxForR, quietly=TRUE)
testXML = ".\\QC_R\\testSim.xml"
DCI_Info_tes…
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I am trying to build a PBPK model for meropenem.
70% of the drug is excreted unchanged in urine. I would like to know if I am missing anything?
Thanks in advance.
kind regards
Mouli
[Meropenam.pd…
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I followed the suggested workflow documented in this forum to add a Tumor container by importing a saved representative Organ.
The Organ did not import successfully in that although all the neigh…
ghost updated
6 years ago