-
Hi,
I am building a PBPK for an orally administered drug (no IV data available as yet). I have renal Clearance value from published literature. I noticed that PK Sim calculates specific clearance fro…
-
Are there plans for a 2018 PKSIM workshop?
-
Hello,
I am dealing with one formulation where I am not able to captureAbsorption & elimination phase.
Can I get some hint which parameters should be modified?
Here I am attaching picture of si…
-
Hello,
I am wondering if there is a way to assign a different plasma protein binding parameter for the same molecule in a selected tissue (i.e. liver or gut) in PK-Sim?
thanks,
Krina
-
Hi
Thank you for your work!
I am trying to simulate large models with mrgsolve. Some models are simulated OK, the another ones result in errors and stop simulation at initial step.
For example I …
-
Hi,
I was wondering enterohepatic recirculation could be added in PK-Sim. I have already added Bile clearance but it doesn't seem to cause the recirculation as it happens in vivo. Hence, AUC is sever…
-
Dear all,
at the moment we are internally discussing the software installation/performance validation of the OSP suite. Does someone have experience in what exactly and how one has to validate the …
-
Dear OSP forum,
Let me explain the clinical scenario here.
We came across an obese patient with a certain infection. We're trying to understand how to dose this patient. The patient is around 140…
-
I am trying to build a PBPK model for Meropenem. I was following the example (Ciprofloxacin) to develop this model.
I do not know how to implement the 70% renal clearance factor into the compound.
P…
-
Hello,
Is there a way to switch to blood flow limited/perfusion limited models for drug kinetics in PK-Sim for small molecules model? By default it uses permeability limited type of model when no l…