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Hy, I am new to PkSim but not to pharmacometrics. I'm trying to run a simulation with PkSim from a literature example (Kuepfer et al). I need to download the "enzyme expression database". I tried to f…
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I am working with Pharmacometrics models which require non-linear functions. So the dosing history of each patient is needed to calculate with a non-linear function the drug concentration in blood at …
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https://github.com/billdenney/Pharmacometrics-Docker/blob/master/Perl_speaks_NONMEM_4.7.0.Dockerfile#L101
That shouldn't be commented out, but the tests that failed are internal to PsN and not rela…
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Is there an easy way to re-order levels of categorical covariates and stratification variables when creating controller?
I tried this and it didn’t work:
```
my_settings = pmx_settings(
use.…
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Hi Tarj,
I'm curious if you've explored containerizing this to facilitate reproducible analysis? And if so if you could share the implementation?
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Hi,
For some examples, we have the following error message when running the run_tool function:
"Error in py_call_impl(callable, dots$args, dots$keywords) :
AttributeError: 'DataInfo' object h…
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Hi again!
I am trying to simulate with uncertainty in the parameters (fixed effect, between subject variability and residual errors) based on a model fitted in NONMEM. I am following the NONMEM xpo…
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Recently I was trying to implement the ODE parameter optimization using autograd function in torch. The data were simulated using the ODEs below (a 2-compartment pharmacokinetic model, in ODE form rat…
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Dear Félicien,
sorry for asking again. Now I am trying to apply mapbayr to a published (NONMEM) model. I probably missed something fundamental in the mrgsolve code, because the mapbayest function s…
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Hello, everyone:
I’m a beginner learning PBPK simulation.
Thanks for your attention.
I want to establish a simulation of pregnant population with PK-SIM and MOBI (v9.1), thus I have followed the…
D-SYD updated
2 years ago