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New equations from:
Garcia, HE, and LI Gordon. 1992. “Oxygen Solubility in Seawater: Better Fitting Equations.” Limnology and Oceanography 37 (6). http://cat.inist.fr/?aModele=afficheN&cpsidt=4757462.…
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I'm currently attempting to synthesise this aminothienopyrimidine (series 2) ana…
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I've come up with a synthetic route to amide-substituted triazolopyrazines - what do you think?
 the ord…
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... in different solvents
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We can in the very short term get _5-10_ compounds tested for hERG.
_We need a list in the next 24 hours_ @alintheopen @tscmacdonald @JoannaUbels
Background discussion at last meeting is here:
http…
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Some triazolopyrazines were found to be metabolically unstable in rats. The team need to determine if this translates to human or mouse microsomes or whether it is solely a problem in rat assays. Some…
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The team need to decide which compounds to synthesise next and it would be good to have 10-20 to focus on.
ESAC made some recommendations:
- Aim for log P between 1.5 and 3.5
- Use more heteroaryls, …