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Dear OSP community,
I’m extending an already developed PBPK model for a compound that is metabolised by the liver to a major metabolite, in order to predict the PK in healthy volunteers.
Firstl…
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### Motivation
In https://github.com/radicle-dev/radicle-link/issues/250, we learned that our `all_metadata`, operating on the glob `refs/namespaces/*/rad/id`, has `libgit2`/`git` going out of the …
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# Models can predict despite invalid parameter values
It is possible for the optimiser to take a model's parameters to a pathological region. When that happens, the user is not protected ag…
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**Submitting author:** @jbuisine (Jérôme BUISINE)
**Repository:** https://github.com/jbuisine/macop
**Version:** v1.2.0
**Editor:** @melissawm
**Reviewer:** @stsievert, @torressa
**Archive:** 10.5…
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Proposed cost model:
* M for a general multiplication (as in R1CS; also the cost of a division);
* m for a constant multiplication (free in R1CS; same as M in Spartan)
* A for an addition/subtrac…
daira updated
3 years ago
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I have been using Stan in anger the past couple of days, which has been enlightening and also a little frustrating.
The reason for this frustration is that a lot of our methods (all sensitivity-bas…
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[Hidden Friends](https://www.justsoftwaresolutions.co.uk/cplusplus/hidden-friends.html) are good because they help with overload resolution and thus are suggested for usage in a modern C++ design.
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mpusz updated
4 years ago
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Hi, thanks a lot for your great work! I find it really interesting!
However, I have a question regarding the loss function. To understand what kind of probability distribution between original `(z…
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This proposal comes in two parts:
1. As the CC controller is a special case of the PS controller (i.e. with infinite constraints), we should change the CC controller to simply call the PS controlle…
H0R5E updated
4 years ago
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As was discussed on Gitter, if a box manifold is defined as such:
1. It truncates the solution components that pass a boundary (retract), and
2. It zeros a gradient component if at the boundary and…